First, the Anti-Federalists predicted that the federal government the Constitution created would increase its power until states were merely secondary considerations. Second, that this powerful federal government would be too big and distant for the people to effectively control, and thus vainglorious men of ambition and avarice would control it to enrich themselves off the common people.Third, that it was unwise to govern a diverse and large population from a remote and distant government that would hold such immense power over the daily lives of common people, and, as a result, politics would become something more primitive than civilized, characterized by constant discord and fighting as different factions tried to control the lives of their fellow citizens.

Source: The Anti-Federalists Predicted Today’s Political Morass, & Can Get Us Out